While I would not travel to the southeast and to the cities along the Syrian border now, certainly the Istanbul area, the Aegean coast with its world class archaeological sites, Cappadocia and the Mediterranean coast with its blue cruises and splendid beach towns are all pretty good bets for a terrific vacation in a hospitable country with excellent food to boot!
Watch Turkish Airlines for fare sales. They offer very competitive rates. I'm a big fan of their nonstop to Istanbul from Boston. Just in case you are curious, here are TripAdvisor's top 10.
Top 2016 Travelers' Choice Destinations